'The approach is obviously powerful, and it is hard to see how solid progress of a factual kind could be made in any other way. It produces answers of the kind known as “robust”. “Robust” does not of course mean “unequivocally true” […] Scientists produce robust answers only because they take great care to tailor the questions. As Sir Peter Medawar said, “Science is the art of the soluble” (within the time and with the tools available). Clearly it is a huge mistake to assume that what is soluble is all there is — but some scientists make this mistake routinely.' – Colin Tudge